How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
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چکیده
منابع مشابه
DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction
DNA methylation has been implicated in chromatin condensation and nuclear organization, especially at sites of constitutive heterochromatin. How this is mediated has not been clear. In this study, using mutant mouse embryonic stem cells completely lacking in DNA methylation, we show that DNA methylation affects nuclear organization and nucleosome structure but not chromatin compaction. In the a...
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in Kornberg and Lorch, 1999). In the classical view, first proposed by Kornberg (1974), each nucleosomal unit is formed by wrapping approximately 146 base pairs of DNA around a histone octamer core particle containing one H3-H4 tetramer and two H2A-H2B dimers. The valid-Genetics Box 800733 ity of this model has been confirmed by determining the crystal structures of the histone octamer, As reve...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2007
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb1338